NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes

NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes

Clinical outcomes after lung transplantation, a life-saving therapy for patients with end-stage lung diseases, are limited by primary graft dysfunction (PGD). PGD is an early form of acute lung injury with no specific pharmacologic therapies. Here, we present a large multicenter study of plasma and...

Full description

Bibliographic Details
Main Authors: Daniel R. Calabrese, Tasha Tsao, Mélia Magnen, Colin Valet, Ying Gao, Beñat Mallavia, Jennifer J. Tian, Emily A. Aminian, Kristin M. Wang, Avishai Shemesh, Elman B. Punzalan, Aartik Sarma, Carolyn S. Calfee, Stephanie A. Christenson, Charles R. Langelier, Steven R. Hays, Jeffrey A. Golden, Lorriana E. Leard, Mary Ellen Kleinhenz, Nicholas A. Kolaitis, Rupal Shah, Aida Venado, Lewis L. Lanier, John R. Greenland, David M. Sayah, Abbas Ardehali, Jasleen Kukreja, S. Samuel Weigt, John A. Belperio, Jonathan P. Singer, Mark R. Looney
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-12-01
Series:JCI Insight
Subjects:
Immunology
Pulmonology
Online Access:https://doi.org/10.1172/jci.insight.164603

Internet

https://doi.org/10.1172/jci.insight.164603

Similar Items