The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

The IgH Eµ-MAR regions promote UNG-dependent error-prone repair to optimize somatic hypermutation

IntoductionTwo scaffold/matrix attachment regions (5’- and 3’-MARsEµ) flank the intronic core enhancer (cEµ) within the immunoglobulin heavy chain locus (IgH). Besides their conservation in mice and humans, the physiological role of MARsEµ is still unclear and their involvement in somatic hypermutat...

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Bibliographic Details
Main Authors: Ophélie A. Martin, Morgane Thomas, Marie Marquet, Charlotte Bruzeau, Armand Garot, Mylène Brousse, Sébastien Bender, Claire Carrion, Jee Eun Choi, Bao Q. Vuong, Patricia J. Gearhart, Robert W. Maul, Sandrine Le Noir, Eric Pinaud
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
B cell
immunoglobulin gene
MARs region
somatic hypermutation (SHM)
UNG
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1030813/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1030813/full

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