Inhibiting CDK4/6 in pancreatic ductal adenocarcinoma via microRNA-21

Inhibiting CDK4/6 in pancreatic ductal adenocarcinoma via microRNA-21

Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, with a 5-year survival rate of 5–10 %. The high mortality rate is due to the asymptomatic progression of clinical features in metastatic stages of the disease, which renders standard therapeutic options futile. PDAC...

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Bibliographic Details
Main Authors: Maria Mortoglou, Francesc Miralles, Rhys Richard Mould, Dipankar Sengupta, Pinar Uysal-Onganer
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:European Journal of Cell Biology
Subjects:
PDAC
Palbociclib
MicroRNAs
CDK4/6 inhibition
Apoptosis
Cell cycle
Online Access:http://www.sciencedirect.com/science/article/pii/S017193352300033X

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http://www.sciencedirect.com/science/article/pii/S017193352300033X

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