NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR

NRF2 Activation in Autophagy Defects Suppresses a Pharmacological Transactivation of the Nuclear Receptor FXR

NF-E2-related factor 2 (NRF2), an antioxidant transcription factor, is activated in autophagy-deficient mice due to the accumulations of p62/SQSTM1 and its subsequent interaction with Kelch-like-ECH-associated protein 1 (KEAP1), an adaptor component for Cullin3-based E3 ubiquitin ligase complex. Far...

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Bibliographic Details
Main Authors: Eun Young Kim, Jae Man Lee
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Antioxidants
Subjects:
autophagy
nrf2
keap1
nuclear receptor
FXR
transactivation
Online Access:https://www.mdpi.com/2076-3921/11/2/370

Internet

https://www.mdpi.com/2076-3921/11/2/370

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