Silencing NUDT21 Attenuates the Mesenchymal Identity of Glioblastoma Cells via the NF-κB Pathway

Silencing NUDT21 Attenuates the Mesenchymal Identity of Glioblastoma Cells via the NF-κB Pathway

The proneural (PN) and mesenchymal (MES) subtypes of glioblastoma multiforme (GBM) are robust and generally consistent with classification schemes. GBMs in the MES subclass are predominantly primary tumors that, compared to PN tumors, exhibit a worse prognosis; thus, understanding the mechanism of M...

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Bibliographic Details
Main Authors: Jia-Cheng Lou, Yu-Long Lan, Jin-Xia Gao, Bin-Bin Ma, Ting Yang, Zhong-Bo Yuan, Hong-Qiang Zhang, Ting-Zhun Zhu, Ning Pan, Song Leng, Gui-Jun Song, Bo Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Molecular Neuroscience
Subjects:
NUDT21
glioblastoma
mesenchymal identity
microarray
therapy
Online Access:http://journal.frontiersin.org/article/10.3389/fnmol.2017.00420/full

Internet

http://journal.frontiersin.org/article/10.3389/fnmol.2017.00420/full

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