Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease

The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To explore this potential linkage, the STN was s...

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Bibliographic Details
Main Authors: Jeremy F Atherton, Eileen L McIver, Matthew RM Mullen, David L Wokosin, D James Surmeier, Mark D Bevan
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-12-01
Series:eLife
Subjects:
basal ganglia
NMDA receptors
astrocytes
KATP channels
mitochondria
glutamate
Online Access:https://elifesciences.org/articles/21616

Internet

https://elifesciences.org/articles/21616

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