Early dysfunction and progressive degeneration of the subthalamic nucleus in mouse models of Huntington's disease
The subthalamic nucleus (STN) is an element of cortico-basal ganglia-thalamo-cortical circuitry critical for action suppression. In Huntington's disease (HD) action suppression is impaired, resembling the effects of STN lesioning or inactivation. To explore this potential linkage, the STN was s...
Main Authors: | Jeremy F Atherton, Eileen L McIver, Matthew RM Mullen, David L Wokosin, D James Surmeier, Mark D Bevan |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2016-12-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/21616 |
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