Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response

Unprecedented Monoterpenoid Polyprenylated Acylphloroglucinols with a Rare 6/6/5/4 Tetracyclic Core, Enhanced MCF-7 Cells’ Sensitivity to Camptothecin by Inhibiting the DNA Damage Response

(±)-Hypersines A–C (<b>1</b>–<b>3</b>), the three pairs of enantiomerically pure monoterpenoid polyprenylated acylphloroglucinols with an unprecedented 6/6/5/4 fused ring system, were isolated from <i>Hypericum elodeoides</i>. Their structures, including absolute...

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Bibliographic Details
Main Authors: Xiang-Zhong Liu, Mi Zhou, Chun-Chun Du, Hong-Hong Zhu, Xi Lu, Shou-Lun He, Guang-Hui Wang, Ting Lin, Wen-Jing Tian, Hai-Feng Chen
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomedicines
Subjects:
Guttiferae
<i>Hypericum elodeoides</i>
acylphloroglucinol
biosynthetic pathway
DNA damage response inhibitor
Online Access:https://www.mdpi.com/2227-9059/9/10/1473

Internet

https://www.mdpi.com/2227-9059/9/10/1473

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