Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy

Injectable photocrosslinking spherical hydrogel-encapsulated targeting peptide-modified engineered exosomes for osteoarthritis therapy

Abstract Osteoarthritis (OA) is a common degenerative joint disease urgently needing effective treatments. Bone marrow mesenchymal stromal cell-derived exosomes (Exo) are considered good drug carriers whereas they have limitations such as fast clearance and low retention. This study aimed to overcom...

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Bibliographic Details
Main Authors: Junlai Wan, Zhiyi He, Renpeng Peng, Xiaopei Wu, Ziqing Zhu, Jiarui Cui, Xiaoxia Hao, Anmin Chen, Jiaming Zhang, Peng Cheng
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Nanobiotechnology
Subjects:
Osteoarthritis
Exosome
Surface modification
Hydrogel
Nanomedicine
Online Access:https://doi.org/10.1186/s12951-023-02050-7

Internet

https://doi.org/10.1186/s12951-023-02050-7

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