PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain

PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain

Abstract Although dyslipidemia in the brain has been implicated in neurodegenerative disorders, the molecular mechanisms underlying its pathogenesis have been largely unclear. PDZD8 is a lipid transfer protein and mice deficient in PDZD8 (PDZD8-KO mice) manifest abnormal accumulation of cholesteryl...

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Bibliographic Details
Main Authors: Yuji Kurihara, Kotone Mitsunari, Nagi Mukae, Hirotaka Shoji, Tsuyoshi Miyakawa, Michiko Shirane
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Molecular Brain
Subjects:
PDZD8
Knockout mouse
Behavior
Dyslipidemia
Lipophagy
Cholesterol
Online Access:https://doi.org/10.1186/s13041-023-01002-4

Internet

https://doi.org/10.1186/s13041-023-01002-4

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