PDZD8-deficient mice manifest behavioral abnormalities related to emotion, cognition, and adaptation due to dyslipidemia in the brain
Abstract Although dyslipidemia in the brain has been implicated in neurodegenerative disorders, the molecular mechanisms underlying its pathogenesis have been largely unclear. PDZD8 is a lipid transfer protein and mice deficient in PDZD8 (PDZD8-KO mice) manifest abnormal accumulation of cholesteryl...
Main Authors: | Yuji Kurihara, Kotone Mitsunari, Nagi Mukae, Hirotaka Shoji, Tsuyoshi Miyakawa, Michiko Shirane |
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Format: | Article |
Language: | English |
Published: |
BMC
2023-01-01
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Series: | Molecular Brain |
Subjects: | |
Online Access: | https://doi.org/10.1186/s13041-023-01002-4 |
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