Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization studyResearch in context

Distinct metabolic features of genetic liability to type 2 diabetes and coronary artery disease: a reverse Mendelian randomization studyResearch in context

Summary: Background: Type 2 diabetes (T2D) and coronary artery disease (CAD) both have known genetic determinants, but the mechanisms through which their associated genetic variants lead to disease onset remain poorly understood. Methods: We used large-scale metabolomics data in a two-sample revers...

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Bibliographic Details
Main Authors: Madeleine L. Smith, Caroline J. Bull, Michael V. Holmes, George Davey Smith, Eleanor Sanderson, Emma L. Anderson, Joshua A. Bell
Format: Article
Language:English
Published: Elsevier 2023-04-01
Series:EBioMedicine
Subjects:
Type 2 diabetes
Coronary artery disease
Mendelian randomization
Metabolism
NMR
UK Biobank
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423000683

Internet

http://www.sciencedirect.com/science/article/pii/S2352396423000683

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