Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart

Gut lumen-leaked microbial DNA causes myocardial inflammation and impairs cardiac contractility in ageing mouse heart

Emerging evidence indicates the critical roles of microbiota in mediating host cardiac functions in ageing, however, the mechanisms underlying the communications between microbiota and cardiac cells during the ageing process have not been fully elucidated. Bacterial DNA was enriched in the cardiomyo...

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Bibliographic Details
Main Authors: Hong Gao, Ke Wang, Jorge A. Suarez, Zhongmou Jin, Karina Cunha e Rocha, Dinghong Zhang, Andrea Farrell, Tyler Truong, Yasemin Tekin, Breanna Tan, Hyun Suh Jung, Julia Kempf, Sushil K. Mahata, Wolfgang H. Dillmann, Jorge Suarez, Wei Ying
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
microbial DNA
extracellular vesicle
Vsig4 + macrophage
inflammageing
cardiac contractility
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1216344/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1216344/full

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