The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism

The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism

The Keap1-Nrf2 pathway plays a central role in the protection of cells against oxidative and xenobiotic stresses. Nrf2 is a potent transcription activator that recognizes a unique DNA sequence known as the antioxidant response element (ARE). Under normal conditions, Nrf2 binds to Keap1 in the cyto...

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Bibliographic Details
Main Authors: Yoichiro eMitsuishi, Hozumi eMotohashi, Masayuki eYamamoto
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Oncology
Subjects:
Glutathione
stress response
tran
redox homeostasis
purine nucleotide
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00200/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00200/full

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