Biological activity of synthesized 5-{1-[(4-chlorophenyl)sulfonyl]piperidin-4-yl}-2-mercapto-1,3,4-oxadiazole derivatives demonstrated by in silico and BSA binding studies

Biological activity of synthesized 5-{1-[(4-chlorophenyl)sulfonyl]piperidin-4-yl}-2-mercapto-1,3,4-oxadiazole derivatives demonstrated by in silico and BSA binding studies

We synthesized a series of compounds bearing pharmacologically important 1,3,4-oxadiazole and piperidine moieties. Spectral data analysis by 1H-NMR, 13C-NMR, IR and EI-MS was used to elucidate the structures of the synthesized molecules. Docking studies explained the different types of interaction o...

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Bibliographic Details
Main Authors: Javed Iqbal, Aziz-ur- Rehman, Muhammad Athar Abbasi, Sabahat Zahra Siddiqui, Shahid Rasool, Muhammad Ashraf, Ambar Iqbal, Sujhla Hamid, Tahir Ali Chohan, Hira Khalid, Sabina Jhaumeer Laulloo, Syed Adnan Ali Shah
Format: Article
Language:English
Published: Universidade de São Paulo 2020-12-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
1,3,4-Oxadiazole
Acetylcholinesterase (AChE) inhibition
Antibacterial activity
Piperidine
Sulfonamide
Urease inhibition
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502020000100596&tlng=en

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