SARS-CoV-2 Delta Variant N Gene Mutations Reduce Sensitivity to the TaqPath COVID-19 Multiplex Molecular Diagnostic Assay

SARS-CoV-2 Delta Variant N Gene Mutations Reduce Sensitivity to the TaqPath COVID-19 Multiplex Molecular Diagnostic Assay

As the SARS-CoV-2 virus evolves, mutations may result in diminished sensitivity to qRT-PCR diagnostic assays. We investigated four polymorphisms circulating in the SARS-CoV-2 Delta lineage that result in <i>N</i> gene target failure (NGTF) on the TaqPath COVID-19 Combo Kit. These mutatio...

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Bibliographic Details
Main Authors: Steven C. Holland, Ajeet Bains, LaRinda A. Holland, Matthew F. Smith, Regan A. Sullins, Nicholas J. Mellor, Alexis W. Thomas, Nathaniel Johnson, Vel Murugan, Efrem S. Lim
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Viruses
Subjects:
SARS-CoV-2
COVID-19
delta variant
N gene dropout
qRT-PCR
Online Access:https://www.mdpi.com/1999-4915/14/6/1316

Internet

https://www.mdpi.com/1999-4915/14/6/1316

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