P2X7 receptor is required for the ototoxicity caused by aminoglycoside in developing cochlear hair cells

P2X7 receptor is required for the ototoxicity caused by aminoglycoside in developing cochlear hair cells

Aminoglycoside antibiotics (AGAs) are widely used in life-threatening infections, but they accumulate in cochlear hair cells (HCs) and result in hearing loss. Increases in adenosine triphosphate (ATP) concentrations and P2X7 receptor expression were observed after neomycin treatment. Here, we demons...

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Bibliographic Details
Main Authors: Cheng Cheng, Jiaoyao Ma, Xiaoling Lu, Panpan Zhang, Xiaohan Wang, Luo Guo, Peifan Li, Ying Wei, Geng-Lin Li, Xia Gao, Yuqiu Zhang, Renjie Chai, Huawei Li, Shan Sun
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Neurobiology of Disease
Subjects:
ATP receptor
Aminoglycoside antibiotics
Ototoxicity
Hair cells
Hearing protection
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001912

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http://www.sciencedirect.com/science/article/pii/S0969996123001912

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