Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice

Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice

Abstract Background Neuroinflammation is thought to be a cause of Alzheimer’s disease (AD), which is partly caused by inadequate mitophagy. As a receptor of mitophagy, we aimed to reveal the regulatory roles of optineurin (OPTN) on neuroinflammation in the pathogenesis of AD. Methods BV2 cells and A...

Full description

Bibliographic Details
Main Authors: Long-Long Cao, Pei-Pei Guan, Shen-Qing Zhang, Yi Yang, Xue-Shi Huang, Pu Wang
Format: Article
Language:English
Published: BMC 2021-12-01
Series:Journal of Neuroinflammation
Subjects:
Optineurin
Absent in melanoma 2
Receptor interacting serine/threonine kinase 1
Proteasome degradation
Alzheimer’s disease
Online Access:https://doi.org/10.1186/s12974-021-02327-4

Internet

https://doi.org/10.1186/s12974-021-02327-4

Similar Items