Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT<sub>2C </sub>receptor-dependent pathways

Blockade of stress-induced increase of glutamate release in the rat prefrontal/frontal cortex by agomelatine involves synergy between melatonergic and 5-HT<sub>2C </sub>receptor-dependent pathways

<p>Abstract</p> <p>Background</p> <p>Agomelatine is a melatonergic receptor agonist and a 5HT<sub>2C </sub>receptor antagonist that has shown antidepressant efficacy. In order to analyze separately the effect of the two receptorial components, rats were chro...

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Main Authors: Racagni Giorgio, Mocaer Elisabeth, Gabriel-Gracia Cecilia, Mallei Alessandra, Grilli Massimo, Musazzi Laura, Bonifacino Tiziana, Milanese Marco, Tardito Daniela, Popoli Maurizio, Bonanno Giambattista
Format: Article
Language:English
Published: BMC 2010-06-01
Series:BMC Neuroscience
Online Access:http://www.biomedcentral.com/1471-2202/11/68

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http://www.biomedcentral.com/1471-2202/11/68

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