Oral Insulin Delivery in Diabetic Rats by PLGA Nanoparticles Combined with a Protease Inhibitor (N-Ethylmaleimide)
Nanoparticles have shown a certain potential to overcome the drawbacks of oral peptide delivery in the gastrointestinal tract such as low peptide stability and permeability. Insulin PLGA NP were prepared using a modified double emulsion solvent evaporation technique. Insulin PLGA NP were composed fr...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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University of Huddersfield Press
2019-04-01
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| Series: | British Journal of Pharmacy |
| Subjects: | |
| Online Access: | https://www.bjpharm.org.uk/article/id/588/ |
| _version_ | 1827942368472465408 |
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| author | Ahmed M Faheem Dalia Abdeĺkader Mohamed A. Osman Paul A. McCarron Sanaa A. El-Gizawy |
| author_facet | Ahmed M Faheem Dalia Abdeĺkader Mohamed A. Osman Paul A. McCarron Sanaa A. El-Gizawy |
| author_sort | Ahmed M Faheem |
| collection | DOAJ |
| description | Nanoparticles have shown a certain potential to overcome the drawbacks of oral peptide delivery in the gastrointestinal tract such as low peptide stability and permeability. Insulin PLGA NP were prepared using a modified double emulsion solvent evaporation technique. Insulin PLGA NP were composed from human insulin (5 mg) encapsulated in PLGA 2.5% (w/v) mixed with PEG (2kDa, 5% w/w) and the external aqueous phase contained 1.25% of PVA. The resulting nanoparticles of 202.6 nm diameter and loaded with 33.86 μg insulin per mg of polymer were utilised in this study to examine the hypoglycaemic effect after combination with a protease inhibitor, N-Ethylmaleimide. |
| first_indexed | 2024-03-13T09:57:19Z |
| format | Article |
| id | doaj.art-1d04c8dc6e3c4532882c14a36e86c9e5 |
| institution | Directory Open Access Journal |
| issn | 2058-8356 |
| language | English |
| last_indexed | 2024-03-13T09:57:19Z |
| publishDate | 2019-04-01 |
| publisher | University of Huddersfield Press |
| record_format | Article |
| series | British Journal of Pharmacy |
| spelling | doaj.art-1d04c8dc6e3c4532882c14a36e86c9e52023-05-23T12:52:00ZengUniversity of Huddersfield PressBritish Journal of Pharmacy2058-83562019-04-014110.5920/bjpharm.588Oral Insulin Delivery in Diabetic Rats by PLGA Nanoparticles Combined with a Protease Inhibitor (N-Ethylmaleimide)Ahmed M Faheem0Dalia Abdeĺkader1Mohamed A. Osman2Paul A. McCarron3Sanaa A. El-Gizawy4University of SunderlandTanta UniversityTanta UniversityUlsterTanta UniversityNanoparticles have shown a certain potential to overcome the drawbacks of oral peptide delivery in the gastrointestinal tract such as low peptide stability and permeability. Insulin PLGA NP were prepared using a modified double emulsion solvent evaporation technique. Insulin PLGA NP were composed from human insulin (5 mg) encapsulated in PLGA 2.5% (w/v) mixed with PEG (2kDa, 5% w/w) and the external aqueous phase contained 1.25% of PVA. The resulting nanoparticles of 202.6 nm diameter and loaded with 33.86 μg insulin per mg of polymer were utilised in this study to examine the hypoglycaemic effect after combination with a protease inhibitor, N-Ethylmaleimide.https://www.bjpharm.org.uk/article/id/588/diabetes mellitusnanoparticleshuman insulinprotease inhibitor |
| spellingShingle | Ahmed M Faheem Dalia Abdeĺkader Mohamed A. Osman Paul A. McCarron Sanaa A. El-Gizawy Oral Insulin Delivery in Diabetic Rats by PLGA Nanoparticles Combined with a Protease Inhibitor (N-Ethylmaleimide) British Journal of Pharmacy diabetes mellitus nanoparticles human insulin protease inhibitor |
| title | Oral Insulin Delivery in Diabetic Rats by PLGA Nanoparticles Combined with a Protease Inhibitor (N-Ethylmaleimide) |
| title_full | Oral Insulin Delivery in Diabetic Rats by PLGA Nanoparticles Combined with a Protease Inhibitor (N-Ethylmaleimide) |
| title_fullStr | Oral Insulin Delivery in Diabetic Rats by PLGA Nanoparticles Combined with a Protease Inhibitor (N-Ethylmaleimide) |
| title_full_unstemmed | Oral Insulin Delivery in Diabetic Rats by PLGA Nanoparticles Combined with a Protease Inhibitor (N-Ethylmaleimide) |
| title_short | Oral Insulin Delivery in Diabetic Rats by PLGA Nanoparticles Combined with a Protease Inhibitor (N-Ethylmaleimide) |
| title_sort | oral insulin delivery in diabetic rats by plga nanoparticles combined with a protease inhibitor n ethylmaleimide |
| topic | diabetes mellitus nanoparticles human insulin protease inhibitor |
| url | https://www.bjpharm.org.uk/article/id/588/ |
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