Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo

Hic-5 antisense oligonucleotide inhibits advanced hepatic fibrosis and steatosis in vivo

Background & Aims: Chronic liver diseases, including metabolic dysfunction-associated steatohepatitis (MASH), pose a significant global health burden. Progressive liver fibrosis can lead to severe outcomes; however, there is a lack of effective therapies targeting advanced fibrosis. Hydrogen...

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Bibliographic Details
Main Authors: Masahito Noguchi, Aya Miyauchi, Yoshiaki Masaki, Masashi Sakaki, Xiao-Feng Lei, Momoko Kobayashi-Tanabe, Akira Miyazaki, Takeshi Aoki, Hitoshi Yoshida, Kohji Seio, Joo-ri Kim-Kaneyama
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:JHEP Reports
Subjects:
MASH
Hic-5
ASO
Liver fibrosis
Extracellular matrix
Online Access:http://www.sciencedirect.com/science/article/pii/S258955592400199X

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http://www.sciencedirect.com/science/article/pii/S258955592400199X

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