ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology.

ADAMTS13 maintains cerebrovascular integrity to ameliorate Alzheimer-like pathology.

Blood-brain barrier (BBB) defects and cerebrovascular dysfunction contribute to amyloid-β (Aβ) brain accumulation and drive Alzheimer disease (AD) pathology. By regulating vascular functions and inflammation in the microvasculature, a disintegrin and metalloprotease with thrombospondin type I motif,...

Full description

Bibliographic Details
Main Authors: Yongliang Cao, Haochen Xu, Yuanbo Zhu, Mei-Juan Shi, Lixiang Wei, Jin Zhang, Shuo Cheng, Yiqian Shi, Haiyang Tong, Lijing Kang, Lu Lu, Haiyu Luo, Xing Yang, Xiaofei Bai, Ranran Wang, Yuanyuan Ma, Yun Wang, Zhongfeng Wang, Kai Zhong, Bing-Qiao Zhao, Wenying Fan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-06-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3000313

Internet

https://doi.org/10.1371/journal.pbio.3000313

Similar Items