Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization.

Mendelian Randomisation (MR) is a powerful tool in epidemiology that can be used to estimate the causal effect of an exposure on an outcome in the presence of unobserved confounding, by utilising genetic variants as instrumental variables (IVs) for the exposure. The effect estimates obtained from MR...

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Bibliographic Details
Main Authors: Eleanor Sanderson, Tom G Richardson, Tim T Morris, Kate Tilling, George Davey Smith
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-07-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010290