Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants

Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants

Daneshgar et al. investigated the role of mitochondrial dysfunction in ADPKD and mitochondria protective agents as potential therapeutics. The authors reported decreased mitochondrial complex activity and downregulation of mitochondrial and metabolic proteins in ADPKD, and proposed mCAT overexpressi...

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Bibliographic Details
Main Authors: Nastaran Daneshgar, Andrew W. Baguley, Peir-In Liang, Fei Wu, Yi Chu, Michael T. Kinter, Gloria A. Benavides, Michelle S. Johnson, Victor Darley-Usmar, Jianhua Zhang, Kung-Sik Chan, Dao-Fu Dai
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02730-w

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https://doi.org/10.1038/s42003-021-02730-w

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