A thioacetamide-induced liver fibrosis model for pre-clinical studies in microminipig

Abstract Drug-induced liver fibrosis models are used in normal and immunosuppressed small animals for transplantation and regenerative medicine to improve liver fibrosis. Although large animal models are needed for pre-clinical studies, they are yet to be established owing to drug sensitivity in ani...

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Bibliographic Details
Main Authors: Kotaro Nishi, Hiroshi Yagi, Mana Ohtomo, Shogo Nagata, Daisuke Udagawa, Tomonori Tsuchida, Toshinori Morisaku, Yuko Kitagawa
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-42144-8