Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1

Phosphoproteomics revealed cellular signals immediately responding to disruption of cancer amino acid homeostasis induced by inhibition of l-type amino acid transporter 1

Abstract Background Cancer-upregulated l-type amino acid transporter 1 (LAT1; SLC7A5) supplies essential amino acids to cancer cells. LAT1 substrates are not only needed for cancer rapid growth, but involved in cellular signaling. LAT1 has been proposed as a potential target for cancer treatment—its...

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Bibliographic Details
Main Authors: Hiroki Okanishi, Ryuichi Ohgaki, Minhui Xu, Hitoshi Endou, Yoshikatsu Kanai
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Cancer & Metabolism
Subjects:
Amino acid transporter system
Drug combinations
Neoplasms
Proteomics
Online Access:https://doi.org/10.1186/s40170-022-00295-8

Internet

https://doi.org/10.1186/s40170-022-00295-8

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