Melatonin-loaded self-healing hydrogel targets mitochondrial energy metabolism and promotes annulus fibrosus regeneration

Melatonin-loaded self-healing hydrogel targets mitochondrial energy metabolism and promotes annulus fibrosus regeneration

Intervertebral disc (IVD) herniation is a major cause of chronic low back pain and disability. The current nucleus pulposus (NP) discectomy effectively relieves pain symptoms, but the annulus fibrosus (AF) defects are left unrepaired. Tissue engineering approaches show promise in treating AF injury...

Full description

Bibliographic Details
Main Authors: Xiayu Hu, Xin Tian, Chunju Yang, Feng Ling, Hao Liu, Xuesong Zhu, Ming Pei, Huilin Yang, Tao Liu, Yong Xu, Fan He
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Materials Today Bio
Subjects:
Annulus fibrosus
Melatonin
Mitochondrial function
Self-healing hydrogel
NRF2
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423002715

Internet

http://www.sciencedirect.com/science/article/pii/S2590006423002715

Similar Items