Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues

Site-Specific Antibody Conjugation to Engineered Double Cysteine Residues

Site-specific antibody conjugations generate homogeneous antibody-drug conjugates with high therapeutic index. However, there are limited examples for producing the site-specific conjugates with a drug-to-antibody ratio (DAR) greater than two, especially using engineered cysteines. Based on availabl...

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Bibliographic Details
Main Authors: Qun Zhou, Josephine Kyazike, Ekaterina Boudanova, Michael Drzyzga, Denise Honey, Robert Cost, Lihui Hou, Francis Duffieux, Marie-Priscille Brun, Anna Park, Huawei Qiu
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceuticals
Subjects:
site-specific antibody-drug conjugation
THIOMAB<sup>TM</sup>
engineered double cysteine
PEGylation
conjugation efficiency and selectivity
Online Access:https://www.mdpi.com/1424-8247/14/7/672

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https://www.mdpi.com/1424-8247/14/7/672

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