Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease

Proteomic alterations in the brain and blood–brain barrier during brain Aβ accumulation in an APP knock-in mouse model of Alzheimer’s disease

Abstract Background Blood–brain barrier (BBB) dysfunction is supposed to be an early event in the development of Alzheimer’s disease (AD). This study aimed to investigate the relationship between BBB alterations and AD progression in terms of amyloid-β peptide (Aβ) accumulation in the brains of huma...

Full description

Bibliographic Details
Main Authors: Shingo Ito, Ryotaro Yagi, Seiryo Ogata, Takeshi Masuda, Takashi Saito, Takaomi Saido, Sumio Ohtsuki
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Fluids and Barriers of the CNS
Subjects:
Alzheimer’s disease
Amyloid-β peptide
Blood–brain barrier
Apolipoprotein
Basement membrane
Proteome analysis
Online Access:https://doi.org/10.1186/s12987-023-00466-9

Internet

https://doi.org/10.1186/s12987-023-00466-9

Similar Items