A Molecular Analysis of Memory B Cell and Antibody Responses Against Plasmodium falciparum Merozoite Surface Protein 1 in Children and Adults From Uganda

A Molecular Analysis of Memory B Cell and Antibody Responses Against Plasmodium falciparum Merozoite Surface Protein 1 in Children and Adults From Uganda

Memory B cells (MBCs) and plasma antibodies against Plasmodium falciparum (Pf) merozoite antigens are important components of the protective immune response against malaria. To gain understanding of how responses against Pf develop in these two arms of the humoral immune system, we evaluated MBC and...

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Bibliographic Details
Main Authors: S. Jake Gonzales, Kathleen N. Clarke, Gayani Batugedara, Rolando Garza, Ashley E. Braddom, Raphael A. Reyes, Isaac Ssewanyana, Kendra C. Garrison, Gregory C. Ippolito, Bryan Greenhouse, Sebastiaan Bol, Evelien M. Bunnik
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
malaria
adaptive immune response
humoral immunity
antibodies
memory B cells
IgM
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.809264/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.809264/full

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