Transplantation of SDF-1α-loaded liver extracellular matrix repopulated with autologous cells attenuated liver fibrosis in a rat model

Transplantation of SDF-1α-loaded liver extracellular matrix repopulated with autologous cells attenuated liver fibrosis in a rat model

Cell-based therapy and tissue engineering are promising substitutes for liver transplantation to cure end-stage liver disorders. However, the limited sources for healthy and functional cells and poor engraftment rate are main challenges to the cell-based therapy approach. On the other hand, feasibil...

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Bibliographic Details
Main Authors: Mostafa Najar-Asl, Hossein Bahadoran, Mohammad-Hossein Asadi, Mona Saheli, Mohammad-Hassan Asghari, Niloofar Sodeifi, Mohammad Kazemi Ashtiani, Massoud Vosough, Hossein Baharvand, Abbas Piryaei
Format: Article
Language:English
Published: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2022-04-01
Series:EXCLI Journal : Experimental and Clinical Sciences
Subjects:
liver extracellular matrix scaffold
stromal derived factor-1α
granulocyte colony stimulating factor
endogenous progenitor cells mobilization
in vivo tissue engineering
liver fibrosis
Online Access:https://www.excli.de/index.php/excli/article/view/4761

Internet

https://www.excli.de/index.php/excli/article/view/4761

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