Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma

Understanding Molecular Mechanisms of Phenotype Switching and Crosstalk with TME to Reveal New Vulnerabilities of Melanoma

Melanoma cells are notorious for their high plasticity and ability to switch back and forth between various melanoma cell states, enabling the adaptation to sub-optimal conditions and therapeutics. This phenotypic plasticity, which has gained more attention in cancer research, is proposed as a new p...

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Bibliographic Details
Main Authors: Ahmad Najem, Laura Soumoy, Malak Sabbah, Mohammad Krayem, Ahmad Awada, Fabrice Journe, Ghanem E. Ghanem
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cells
Subjects:
melanoma
phenotype switching
tumor microenvironment
oxidative stress
metabolic reprogramming
therapeutic strategies
Online Access:https://www.mdpi.com/2073-4409/11/7/1157

Internet

https://www.mdpi.com/2073-4409/11/7/1157

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