Comprehensive analysis of fibroblast activation protein expression across 23 tumor indications: insights for biomarker development in cancer immunotherapies

Comprehensive analysis of fibroblast activation protein expression across 23 tumor indications: insights for biomarker development in cancer immunotherapies

IntroductionFibroblast activation protein (FAP) is predominantly upregulated in various tumor microenvironments and scarcely expressed in normal tissues.MethodsWe analyzed FAP across 1216 tissue samples covering 23 tumor types and 70 subtypes.ResultsElevated FAP levels were notable in breast, pancre...

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Bibliographic Details
Main Authors: Sebastian Dziadek, Anton Kraxner, Wei-Yi Cheng, Tai-Hsien Ou Yang, Mike Flores, Noah Theiss, Tsu-Shuen Tsao, Emilia Andersson, Suzana Vega Harring, Ann-Marie E. Bröske, Maurizio Ceppi, Volker Teichgräber, Jehad Charo
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
fibroblast activation protein
immunohistochemistry
mRNA expression
immunotherapy
clinical outcomes
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352615/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1352615/full

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