Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis

Repurposing the antipsychotic drug amisulpride for targeting synovial fibroblast activation in arthritis

Synovial fibroblasts (SFs) are key pathogenic drivers in rheumatoid arthritis (RA). Their in vivo activation by TNF is sufficient to orchestrate full arthritic pathogenesis in animal models, and TNF blockade proved efficacious for a high percentage of patients with RA albeit coinducing rare but seri...

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Bibliographic Details
Main Authors: Dimitra Papadopoulou, Fani Roumelioti, Christos Tzaferis, Panagiotis Chouvardas, Anna-Kathrine Pedersen, Filippos Charalampous, Eleni Christodoulou-Vafeiadou, Lydia Ntari, Niki Karagianni, Maria C. Denis, Jesper V. Olsen, Alexios N. Matralis, George Kollias
Format: Article
Language:English
Published: American Society for Clinical investigation 2023-05-01
Series:JCI Insight
Subjects:
Therapeutics
Online Access:https://doi.org/10.1172/jci.insight.165024

Internet

https://doi.org/10.1172/jci.insight.165024

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