Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators

Investigation of piperazines as human carbonic anhydrase I, II, IV and VII activators

Four human (h) carbonic anhydrase isoforms (CA, EC 4.2.1.1), hCA I, II, IV, and VII, were investigated for their activation profile with piperazines belonging to various classes, such as N-aryl-, N-alkyl-, N-acyl-piperazines as well as 2,4-disubstituted derivatives. As the activation mechanism invol...

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Bibliographic Details
Main Authors: Andrea Angeli, Niccolò Chiaramonte, Dina Manetti, Maria Novella Romanelli, Claudiu T. Supuran
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
Carbonic anhydrase
activator
amine
piperazine
proton transfer
cognition enhancement
Online Access:http://dx.doi.org/10.1080/14756366.2017.1417277

Internet

http://dx.doi.org/10.1080/14756366.2017.1417277

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