Embryoid Body Cells from Human Embryonic Stem Cells Overexpressing Dopaminergic Transcription Factors Survive and Initiate Neurogenesis via Neural Rosettes in the Substantia Nigra

Embryoid Body Cells from Human Embryonic Stem Cells Overexpressing Dopaminergic Transcription Factors Survive and Initiate Neurogenesis via Neural Rosettes in the Substantia Nigra

Transplantation of immature dopaminergic neurons or neural precursors derived from embryonic stem cells (ESCs) into the substantia nigra pars compacta (SNpc) is a potential therapeutic approach for functional restitution of the nigrostriatal pathway in Parkinson’s disease (PD). However, further stud...

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Bibliographic Details
Main Authors: Rodrigo Ramos-Acevedo, Carmen Alejandra Morato-Torres, Francisco J. Padilla-Godínez, Luis Daniel Bernal-Conde, Marcela Palomero-Rivero, Faria Zafar, Omar Collazo-Navarrete, Luis O. Soto-Rojas, Birgitt Schüle, Magdalena Guerra-Crespo
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Brain Sciences
Subjects:
embryoid body cells
human embryonic stem cells
stem-cell transplantation
substantia nigra
neural rosettes
transcription factors
Online Access:https://www.mdpi.com/2076-3425/13/2/329

Internet

https://www.mdpi.com/2076-3425/13/2/329

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