Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties

Cilastatin protects against tacrolimus-induced nephrotoxicity via anti-oxidative and anti-apoptotic properties

Abstract Background Cilastatin (CL) is an inhibitor of dehydropeptidase-I, which is safely used in clinical practice to prevent nephrotoxicity of antibiotics. Tacrolimus (TAC) is the most important immunosuppressant in renal transplantation, but it causes considerable nephrotoxicity. We evaluated th...

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Bibliographic Details
Main Authors: Kang Luo, Sun Woo Lim, Jian Jin, Long Jin, Hyo Wook Gil, Dai Sig Im, Hyeon Seok Hwang, Chul Woo Yang
Format: Article
Language:English
Published: BMC 2019-06-01
Series:BMC Nephrology
Subjects:
Cilastatin
Tacrolimus
Nephrotoxicity
Online Access:http://link.springer.com/article/10.1186/s12882-019-1399-6

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http://link.springer.com/article/10.1186/s12882-019-1399-6

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