MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression

MRCK-Alpha and Its Effector Myosin II Regulatory Light Chain Bind ABCB4 and Regulate Its Membrane Expression

ABCB4, is an adenosine triphosphate-binding cassette (ABC) transporter localized at the canalicular membrane of hepatocytes, where it mediates phosphatidylcholine secretion into bile. Gene variations of ABCB4 cause different types of liver diseases, including progressive familial intrahepatic choles...

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Bibliographic Details
Main Authors: Alix Bruneau, Jean-Louis Delaunay, Anne-Marie Durand-Schneider, Virginie Vauthier, Amel Ben Saad, Lynda Aoudjehane, Haquima El Mourabit, Romain Morichon, Thomas Falguières, Jérémie Gautheron, Chantal Housset, Tounsia Aït-Slimane
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cells
Subjects:
ABC transporters
bile secretion
cholestatic liver diseases
membrane internalization
Online Access:https://www.mdpi.com/2073-4409/11/4/617

Internet

https://www.mdpi.com/2073-4409/11/4/617

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