Cardiac-specific renalase overexpression alleviates CKD-induced pathological cardiac remodeling in mice

Cardiac-specific renalase overexpression alleviates CKD-induced pathological cardiac remodeling in mice

IntroductionCKD-induced pathological cardiac remodeling is characterized by myocardial hypertrophy and cardiac fibrosis. The available therapeutic options are limited, it is thus urgently needed to identify novel therapeutic targets. Renalase (RNLS) is a newly discovered protein secreted by the kidn...

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Bibliographic Details
Main Authors: Yi Wang, Linnan Bai, Jiejun Wen, Fangfei Zhang, Sijie Gu, Feng Wang, Jianyong Yin, Niansong Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
renalase
pathological cardiac remodeling
CKD
cardiac fibrosis
cardiac fibroblasts
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1061146/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.1061146/full

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