Cardiac-specific renalase overexpression alleviates CKD-induced pathological cardiac remodeling in mice

Cardiac-specific renalase overexpression alleviates CKD-induced pathological cardiac remodeling in mice

IntroductionCKD-induced pathological cardiac remodeling is characterized by myocardial hypertrophy and cardiac fibrosis. The available therapeutic options are limited, it is thus urgently needed to identify novel therapeutic targets. Renalase (RNLS) is a newly discovered protein secreted by the kidn...

Full description

Bibliographic Details
Main Authors:	Yi Wang, Linnan Bai, Jiejun Wen, Fangfei Zhang, Sijie Gu, Feng Wang, Jianyong Yin, Niansong Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	renalase pathological cardiac remodeling CKD cardiac fibrosis cardiac fibroblasts
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2022.1061146/full

Similar Items

The Multi-Faceted Nature of Renalase for Mitochondrial Dysfunction Improvement in Cardiac Disease
by: Dijana Stojanovic, et al.
Published: (2023-06-01)

Editorial: The cardiac stroma in homeostasis and disease
by: Isotta Chimenti, et al.
Published: (2023-07-01)

Ameliorating the Fibrotic Remodeling of the Heart through Direct Cardiac Reprogramming
by: Emre Bektik, et al.
Published: (2019-07-01)

Circulating Renalase as Predictor of Renal and Cardiovascular Outcomes in Pre-Dialysis CKD Patients: A 5-Year Prospective Cohort Study
by: Ana Cerqueira, et al.
Published: (2021-03-01)

Chronic intermittent hypoxia accelerates cardiac dysfunction and cardiac remodeling during cardiac pressure overload in mice and can be alleviated by PHD3 overexpression
by: Xuan Xu, et al.
Published: (2022-09-01)

PFKFB3 Inhibitor 3PO Reduces Cardiac Remodeling after Myocardial Infarction by Regulating the TGF-β1/SMAD2/3 Pathway
by: Qian Yang, et al.
Published: (2023-07-01)

Arteriovenous fistula-induced cardiac remodeling shows cardioprotective features in mice
by: Shin-Rong Lee, MD, PhD, et al.
Published: (2021-01-01)

Relation of the renin–angiotensin–aldosterone system with potential cardiac injury and remodelling: the SABPA study
by: Lebo F. Gafane-Matemane, et al.
Published: (2020-01-01)

Association of renalase genotypes with their serum levels in Iraqi hypertensive patients
by: Iqbal, et al.
Published: (2022-09-01)

Cardiomyocyte—Endothelial Cell Interactions in Cardiac Remodeling and Regeneration
by: Virpi Talman, et al.
Published: (2018-07-01)

Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway
by: Lina Ba, et al.
Published: (2024-01-01)

Silencing circ_0006104 inhibits the proliferation, activation and collagen synthesis by mouse cardiac fibroblasts through up-regulation of miR-370-3p
by: LI Ya-fei, DU Ying-qiang, WANG Ze-mu, ZHANG Jun
Published: (2022-11-01)

Oxidative Stress as a Therapeutic Target of Cardiac Remodeling
by: Danilo Martins, et al.
Published: (2022-11-01)

Differential Susceptibility to Particulate Matter-Induced Cardiac Remodeling and Senescence: A Comparative Study in Young and Aged Mice
by: Dunia Waked, et al.
Published: (2025-01-01)

A time-series minimally invasive transverse aortic constriction mouse model for pressure overload-induced cardiac remodeling and heart failure
by: Xia Wang, et al.
Published: (2023-02-01)

Channelling the Force to Reprogram the Matrix: Mechanosensitive Ion Channels in Cardiac Fibroblasts
by: Leander Stewart, et al.
Published: (2021-04-01)

Lutein attenuates angiotensin II- induced cardiac remodeling by inhibiting AP-1/IL-11 signaling
by: Youming Chen, et al.
Published: (2021-08-01)

Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts
by: Raghu Sundaresan Nagalingam, et al.
Published: (2024-12-01)

Cardiac Remodeling in the Absence of Cardiac Contractile Dysfunction Is Sufficient to Promote Cancer Progression
by: Lama Awwad, et al.
Published: (2022-03-01)

HEART REMODELING IN OVERWEIGHT AND OBESITY WITH CARDIAC COMORBIDITIES
by: I. V. Logacheva, et al.
Published: (2017-05-01)

Cardiac remodeling and apoptosis before and after restoration of euthyroidism in Graves’ thyrotoxicosis
by: Wael Refaie, et al.
Published: (2012-06-01)

Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation
by: Eliot G. Peyster, MD, MSc, et al.
Published: (2025-02-01)

Association between reverse electrical remodeling and cardiac fibrosis markers in patients with cardiac resynchronization therapy
by: Hamza Sunman, et al.
Published: (2018-03-01)

Mast Cells in Cardiac Remodeling: Focus on the Right Ventricle
by: Argen Mamazhakypov, et al.
Published: (2024-02-01)

ERK3 is involved in regulating cardiac fibroblast function
by: Pramod Sahadevan, et al.
Published: (2024-06-01)

Overexpression of NOX2 Exacerbates AngII-Mediated Cardiac Dysfunction and Metabolic Remodelling
by: Synne S. Hansen, et al.
Published: (2022-01-01)

Effects of aging and type 2 diabetes on cardiac structure and function: Underlying mechanisms
by: Justina P. Nguyen, et al.
Published: (2023-03-01)

Epigenetic Regulation of Fibroblasts and Crosstalk between Cardiomyocytes and Non-Myocyte Cells in Cardiac Fibrosis
by: Liangyu Chu, et al.
Published: (2023-09-01)

Cardiomyocyte-Specific Deletion of Orai1 Reveals Its Protective Role in Angiotensin-II-Induced Pathological Cardiac Remodeling
by: Sebastian Segin, et al.
Published: (2020-04-01)

Removal of cardiac AL amyloid with positive remodelling of cardiomyocytes and of restrictive cardiomyopathy
by: Andrea Frustaci, et al.
Published: (2022-12-01)

A Review of Therapeutic Strategies against Cardiac Fibrosis: From Classical Pharmacology to Novel Molecular, Epigenetic, and Biotechnological Approaches
by: Erica Floris, et al.
Published: (2023-08-01)

Limiting extracellular matrix expansion in diet-induced obese mice reduces cardiac insulin resistance and prevents myocardial remodelling
by: Vishal Musale, et al.
Published: (2024-08-01)

Voltage-dependent anion channel 1 (VDAC1) overexpression alleviates cardiac fibroblast activation in cardiac fibrosis via regulating fatty acid metabolism
by: Geer Tian, et al.
Published: (2023-11-01)

Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition
by: Zehao Zhuang, et al.
Published: (2024-10-01)

Metabolic alterations and therapeutic targets ofpathological cardiac remodeling
by: Zhao Mingming, et al.
Published: (2020-12-01)

Transcriptome and proteome profiling of activated cardiac fibroblasts supports target prioritization in cardiac fibrosis
by: Maria Raquel Moita, et al.
Published: (2022-12-01)

Role of Nutrients and Foods in Attenuation of Cardiac Remodeling through Oxidative Stress Pathways
by: Taline Lazzarin, et al.
Published: (2022-10-01)

The role of Galectin-3 in cardiac remodeling
by: Jingni He, et al.
Published: (2016-01-01)

Engineering a robust and anisotropic cardiac-specific extracellular matrix scaffold for cardiac patch tissue engineering
by: Te-An Chen, et al.
Published: (2024-08-01)

Induction of Proteasome Subunit Low Molecular Weight Protein (LMP)-2 Is Required to Induce Active Remodeling in Adult Rat Ventricular Cardiomyocytes
by: Antonia Petersen, et al.
Published: (2020-05-01)