Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor

Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor

<p>Abstract</p> <p>Background</p> <p>Traumatic brain injury (TBI) induces activation of microglia. Activated microglia can in turn increase secondary injury and impair recovery. This innate immune response requires hours to days to become fully manifest, thus providing...

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Bibliographic Details
Main Authors: d'Avila Joana C, Lam Tina I, Bingham Deborah, Shi Jian, Won Seok, Kauppinen Tiina M, Massa Stephen, Liu Jialing, Swanson Raymond A
Format: Article
Language:English
Published: BMC 2012-02-01
Series:Journal of Neuroinflammation
Subjects:
Astrocyte
Behavioral
Forelimb
Inflammation
Microglia
Minocycline
Poly(ADP-ribose) polymerase
traumatic brain injury
Online Access:http://www.jneuroinflammation.com/content/9/1/31

Internet

http://www.jneuroinflammation.com/content/9/1/31

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