Decoding brain state transitions in the pedunculopontine nucleus: cooperative phasic and tonic mechanisms

Cholinergic neurons of the pedunculopontine nucleus (PPN) are most active during the waking state. Their activation is deemed to cause a switch in the global brain activity from sleep to wakefulness, while their sustained discharge may contribute to upholding the waking state and enhancing arousal....

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Bibliographic Details
Main Authors: Anne ePetzold, Miguel eValencia, Balazs ePal, Juan eMena-Segovia
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-10-01
Series:Frontiers in Neural Circuits
Subjects:
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00068/full