Ascl1 phospho-status regulates neuronal differentiation in a Xenopus developmental model of neuroblastoma

Neuroblastoma (NB), although rare, accounts for 15% of all paediatric cancer mortality. Unusual among cancers, NBs lack a consistent set of gene mutations and, excluding large-scale chromosomal rearrangements, the genome seems to be largely intact. Indeed, many interesting features of NB suggest tha...

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Bibliographic Details
Main Authors: Luke A. Wylie, Laura J. A. Hardwick, Tatiana D. Papkovskaia, Carol J. Thiele, Anna Philpott
Format: Article
Language:English
Published: The Company of Biologists 2015-05-01
Series:Disease Models & Mechanisms
Subjects:
Online Access:http://dmm.biologists.org/content/8/5/429