Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors

Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors

Feng et al. compare the genome-wide binding and activity of two Drosophila Hox transcription factors that determine the identities of different fly legs. For binding events that are Hox specific, two cofactors, Exd and Dll, are used to achieve specificity in non-overlapping leg domains.

Bibliographic Details
Main Authors: Siqian Feng, Chaitanya Rastogi, Ryan Loker, William J. Glassford, H. Tomas Rube, Harmen J. Bussemaker, Richard S. Mann
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-31501-2

Internet

https://doi.org/10.1038/s41467-022-31501-2

Similar Items