Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors
Feng et al. compare the genome-wide binding and activity of two Drosophila Hox transcription factors that determine the identities of different fly legs. For binding events that are Hox specific, two cofactors, Exd and Dll, are used to achieve specificity in non-overlapping leg domains.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31501-2 |
| _version_ | 1818235099867512832 |
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| author | Siqian Feng Chaitanya Rastogi Ryan Loker William J. Glassford H. Tomas Rube Harmen J. Bussemaker Richard S. Mann |
| author_facet | Siqian Feng Chaitanya Rastogi Ryan Loker William J. Glassford H. Tomas Rube Harmen J. Bussemaker Richard S. Mann |
| author_sort | Siqian Feng |
| collection | DOAJ |
| description | Feng et al. compare the genome-wide binding and activity of two Drosophila Hox transcription factors that determine the identities of different fly legs. For binding events that are Hox specific, two cofactors, Exd and Dll, are used to achieve specificity in non-overlapping leg domains. |
| first_indexed | 2024-12-12T11:48:35Z |
| format | Article |
| id | doaj.art-1d593ab08c24437783d53d88f829132d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-12T11:48:35Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-1d593ab08c24437783d53d88f829132d2022-12-22T00:25:22ZengNature PortfolioNature Communications2041-17232022-07-0113111910.1038/s41467-022-31501-2Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactorsSiqian Feng0Chaitanya Rastogi1Ryan Loker2William J. Glassford3H. Tomas Rube4Harmen J. Bussemaker5Richard S. Mann6Department of Biochemistry and Molecular Biophysics, Columbia UniversityDepartment of Biological Sciences, Columbia UniversityDepartment of Biochemistry and Molecular Biophysics, Columbia UniversityDepartment of Biochemistry and Molecular Biophysics, Columbia UniversityDepartment of Biological Sciences, Columbia UniversityDepartment of Biological Sciences, Columbia UniversityDepartment of Biochemistry and Molecular Biophysics, Columbia UniversityFeng et al. compare the genome-wide binding and activity of two Drosophila Hox transcription factors that determine the identities of different fly legs. For binding events that are Hox specific, two cofactors, Exd and Dll, are used to achieve specificity in non-overlapping leg domains.https://doi.org/10.1038/s41467-022-31501-2 |
| spellingShingle | Siqian Feng Chaitanya Rastogi Ryan Loker William J. Glassford H. Tomas Rube Harmen J. Bussemaker Richard S. Mann Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors Nature Communications |
| title | Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors |
| title_full | Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors |
| title_fullStr | Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors |
| title_full_unstemmed | Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors |
| title_short | Transcription factor paralogs orchestrate alternative gene regulatory networks by context-dependent cooperation with multiple cofactors |
| title_sort | transcription factor paralogs orchestrate alternative gene regulatory networks by context dependent cooperation with multiple cofactors |
| url | https://doi.org/10.1038/s41467-022-31501-2 |
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