More evidence for widespread antagonistic pleiotropy in polymorphic disease alleles

IntroductionMany loci segregate alleles classified as “genetic diseases” due to their deleterious effects on health. However, some disease alleles have been reported to show beneficial effects under certain conditions or in certain populations. The beneficial effects of these antagonistically pleiot...

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Bibliographic Details
Main Authors: Cynthia Lockwood, Ashley S. Vo, Hanna Bellafard, Ashley J. R. Carter
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-06-01
Series:Frontiers in Genetics
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2024.1404516/full