The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

The structure of a Plasmodium vivax Tryptophan Rich Antigen domain suggests a lipid binding function for a pan-Plasmodium multi-gene family

Abstract Tryptophan Rich Antigens (TRAgs) are encoded by a multi-gene family found in all Plasmodium species, but are significantly expanded in P. vivax and closely related parasites. We show that multiple P. vivax TRAgs are expressed on the merozoite surface and that one, PVP01_0000100 binds red bl...

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Bibliographic Details
Main Authors: Prasun Kundu, Deboki Naskar, Shannon J. McKie, Sheena Dass, Usheer Kanjee, Viola Introini, Marcelo U. Ferreira, Pietro Cicuta, Manoj Duraisingh, Janet E. Deane, Julian C. Rayner
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40885-8

Internet

https://doi.org/10.1038/s41467-023-40885-8

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