Gain of chromosome 21 increases the propensity for P2RY8::CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression

Gain of chromosome 21 increases the propensity for P2RY8::CRLF2 acute lymphoblastic leukemia via increased HMGN1 expression

Acute lymphoblastic leukemia (ALL) patients with a gain of chromosome 21, intrachromosomal amplification of chromosome 21 (iAMP21), or Down syndrome (DS), have increased expression of genes in the DS critical region (DSCR) of chromosome 21, including the high-mobility group nucleosome-binding protei...

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Bibliographic Details
Main Authors: Elyse C. Page, Susan L. Heatley, Jacqueline Rehn, Paul Q. Thomas, David T. Yeung, Deborah L. White
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Oncology
Subjects:
leukemia
gene expression
HMGN1
P2RY8::CRLF2
CRISPR/Cas9
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1177871/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1177871/full

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