Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo

Minimal B Cell Extrinsic IgG Glycan Modifications of Pro- and Anti-Inflammatory IgG Preparations in vivo

Select residues in the biantennary sugar moiety attached to the fragment crystallizable of immunoglobulin G (IgG) antibodies can modulate IgG effector functions. Thus, afucosylated IgG glycovariants have enhanced cytotoxic activity, whereas IgG glycovariants rich in terminal sialic acid residues can...

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Bibliographic Details
Main Authors: Anja Schaffert, Maja Hanić, Mislav Novokmet, Olga Zaytseva, Jasminka Krištić, Anja Lux, Lars Nitschke, Matthias Peipp, Marija Pezer, René Hennig, Erdmann Rapp, Gordan Lauc, Falk Nimmerjahn
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Immunology
Subjects:
glycosylation
sialylation
IVIg
IgG
B cells
antibody
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03024/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03024/full

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