Taxifolin Suppresses Inflammatory Responses of High-Glucose-Stimulated Mouse Microglia by Attenuating the TXNIP–NLRP3 Axis

Taxifolin Suppresses Inflammatory Responses of High-Glucose-Stimulated Mouse Microglia by Attenuating the TXNIP–NLRP3 Axis

Type 2 diabetes mellitus is associated with an increased risk of dementia, potentially through multifactorial pathologies, including neuroinflammation. Therefore, there is a need to identify novel agents that can suppress neuroinflammation and prevent cognitive impairment in diabetes. In the present...

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Bibliographic Details
Main Authors: Masayo Iwasa, Hisashi Kato, Kaori Iwashita, Hajime Yamakage, Sayaka Kato, Satoshi Saito, Masafumi Ihara, Hideo Nishimura, Atsuhiko Kawamoto, Takayoshi Suganami, Masashi Tanaka, Noriko Satoh-Asahara
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Nutrients
Subjects:
antioxidant
high glucose
inflammasome
microglia
neuroinflammation
radical scavenger
Online Access:https://www.mdpi.com/2072-6643/15/12/2738

Internet

https://www.mdpi.com/2072-6643/15/12/2738

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